An international team of researchers from the United States, Japan, France, China and other countries found that more than 40 new DNA regions increase the risk of rheumatoid arthritis. Relevant papers were published online in the international academic journal Nature recently.
Rheumatoid arthritis is a rheumatism caused by disorders of the immune system and characterized by joint inflammation. The disease has a high incidence and high disability rate. The study believes that 65% of the risk of rheumatoid arthritis is caused by genetic factors. Previously, researchers have found 59 genes related to the risk of rheumatoid arthritis in the entire genome.
In the study, the Chinese team conducted a large-scale genetic epidemiological study involving thousands of Chinese Han patients and participated in the discovery of 42 new genes for the onset of rheumatoid arthritis, bringing the number of known susceptibility genes for the disease to 101, and identified a series of unreported genes related to the risk of rheumatoid arthritis in Han people, and revealed the similarities and differences in genetic background with European rheumatoid arthritis patients.
Professor Xu Huji, the leader of the Chinese team in the project and the director of the Department of Rheumatology and Immunology of the Changzheng Hospital Affiliated to the Second Military Medical University, said: "This study proves that the rheumatoid arthritis of Europeans and the rheumatoid arthritis of Han people are genetic It is similar. It is inferred that more effective therapies in one race will also work in another race. "In addition, researchers found in the study of human rheumatoid arthritis in the Han nationality, the disease mainly has ACPA positive and ACPA negative This type, because the two have similar causes, so an effective treatment is effective for both types of patients.
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