Gel permeation chromatography or size exclusion chromatography (GPC / SEC) is the main analysis method commonly used in polymers, macromolecules and proteins. The main reason is that it can quantitatively characterize molecular weight and molecular weight distribution data. People usually divide the above analysis method into two steps. The first step: use a chromatographic column with microporous packing material with appropriate characteristics to separate the dissolved sample according to molecular size / volume; the second step: analyze the separated sample using an appropriate detection instrument. In this article, Stephen Ball, product marketing manager from Malvern Instruments, will explain to you the detector technology that can be used and its potential for improving analysis efficiency.
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