According to a report by the British Daily Mail, at present, scientists have successfully cultivated artificial skin in the laboratory for the first time, which can replace the drug experimental animal and cosmetic testing.
Scientists from the United Kingdom and the United States have now produced a 1 cm wide epidermal sheet (the outermost layer of skin), which is cultivated by stem cells and has similar properties to real skin. The epidermis forms a "protective barrier" between the body and the external environment to prevent water loss and protect against microorganisms and toxins.
Prior to this, engineers could not cultivate the outer layer of skin with functional barriers in drug testing. Scientists believe that artificial skin grown in the laboratory in the future can be used for medical lotion testing, as well as creams or cosmetics that make animals suffer. At the same time, it also provides a model for investigating skin conditions such as eczema.
Last month, the United Kingdom banned the use of animal testing cosmetics and illegally imported or sold materials for animal testing in the European Union. However, cosmetic testing is still being conducted in other parts of the world, including China and the United States.
Dr. Dusko Ilic, a research team at King's College, University of London, engaged in this research, said: "Our latest method can be used to cultivate more laboratory human epidermal equivalents, so it can be scaled up Used for commercial testing of drugs and cosmetics. "
Human epidermal equivalents can grow into different skin types, depending on the source of stem cells used. At the same time, they can be adapted to study a range of skin conditions and skin sensitivity of different groups.
This artificial skin is derived from induced multifunctional stem cells (iPS), which are formed in adult connective tissue genetic variants and donated to fibroblasts. Induced multifunctional stem cells have the same properties as embryonic stem cells, including the ability to develop into any tissue of the body.
The laboratory's step-by-step operation can make induced multifunctional stem cells into keratinocytes, which is the dominant cell type in the outer layer of the skin, which can then be pieced together to form real skin. Scientists call this kind of artificial skin "3D epidermal equivalent". Tests have shown that there is no significant difference in structure and function between artificial skin and real human skin. The research report was published in the "Stem Cell Report" magazine.
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