β-Aminoethylimidazole is a key biochemical compound used in various research applications, particularly in ELISA kits for different species such as Human, Monkey, Pig, Rabbit, Sheep, Mouse, Rat, Camel, Chicken, Deer, Horse, Fish, Guinea Pig, Duck, Goat, and more. The English name of this compound is Histamine, also known as 2-(4-Imidazolyl)ethylamine, 2-imidazolylamine, β-aminoethylimidazole, β-aminoethylglycine, or 1H-imidazole-4-ethylamine. Its CAS number is 51-45-6, with a molecular formula of C5H9N3 and a molecular weight of 111.15 g/mol.
This high-purity compound (≥98.0%) appears as a white crystalline powder or crystal, sensitive to air and moisture. It is hygroscopic and should be stored at 2–8°C, away from light to maintain stability. It is soluble in water, ethanol, and hot chloroform, slightly soluble in ether, and has a boiling point of 209–210°C under 2.40 kPa pressure.
The product meets strict quality standards: sulfate content ≤0.02%, heavy metals ≤10 ppm, arsenic salts ≤10 ppm, and loss on drying ≤0.3%. It is commonly used in biochemical studies due to its role as an endogenous agonist for H1 and H2 histamine receptors. H1 receptor activation leads to calcium mobilization, while H2 receptor activation stimulates adenylate cyclase activity in neurons and enhances nitric oxide synthase function.
It is important to note that β-Aminoethylimidazole is irritating and potentially toxic, with a median lethal dose of 2020 mg/kg when administered intraperitoneally in mice. Proper handling and safety precautions are recommended during use. This compound is widely utilized in research laboratories for immunoassay development and biological activity studies across multiple species.
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