Stem cell therapy restores the function of multiple sclerosis mice


Multiple sclerosis (MS) is the most common demyelinating disease in the central nervous system. The lesions involve the paraventricular white matter, optic nerve and spinal cord. At present, mice that are severely disabled because of MS have recovered their walking ability less than two weeks after treatment with human neural stem cells.

In stark contrast to active healthy mice, these MS mice must be fed with the forepaws because they cannot stand long enough to eat and drink independently. When scientists transplanted human neural stem cells into MS mice, they initially predicted no effect. They believe that mice reject these cells, just like rejection in organ transplants.

More than 2.3 million people worldwide suffer from multiple sclerosis, in which the immune system attacks myelin. The damage caused by the inhibition of the transmission of nerve impulses, resulting in a variety of symptoms, including walking difficulties, visual impairment, fatigue and pain.

Currently, FDA-approved drugs can slow down the early forms of the disease by suppressing the immune system. In recent years, scientists have turned their attention to finding ways to stop or reverse multiple sclerosis. This finding in this study can help patients in the progressive phase of multiple sclerosis because they have no treatment.

The results of the study indicate that the mouse exhibits at least partial reversal of symptoms. The immune attack became dull and the damaged myelin was repaired, explaining their dramatic recovery. Loring described the reasons behind this new result. They said: "Our method of using neural stem cells has proven to be very important."

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