Japanese researchers report that induced multifunctional stem cells (iPS cells) can be used to cultivate immune cells with anti-cancer functions in large numbers, and it is expected that new immunotherapies for cancer treatment will be developed on this basis.
The researchers extracted immune cells that are attacking cancer cells from some cancer patients with malignant melanoma, and used these immune cells called "T lymphocytes" to cultivate iPS cells. iPS cells are a type of cells that are cultivated after extracting specific human cells and implanting special genes into them. They have the potential to differentiate into a variety of human tissue cells.
In this study, these iPS cells were again cultivated and differentiated into T lymphocytes. The key is that the T lymphocytes obtained in this way still have the function of attacking cancer cells. The research team pointed out that when recognizing cancer cells, T lymphocytes will "remember" the characteristics of cancer cells by changing the gene arrangement. This "memory" can be passed to iPS cells, and then T lymphocytes can be cultivated Cancer cells can be attacked as before.
According to reports, the existing immunotherapy often simply stimulates the patient's T lymphocytes to proliferate, but because it is difficult to increase by a large amount, the effect is very limited. The method developed this time can cultivate a large number of T lymphocytes, so it is expected to solve this problem.
Researchers published a paper in the new issue of "Cell · Stem Cell" magazine, saying that this technology is still in the stage of test tube experiments, and it is possible to develop new immunotherapy for cancer on the basis of it in the future. Kawamoto Hiroshi, a researcher at the Japan Institute of Physics and Chemistry, who is leading the research, said that the next step will be to confirm its effects through animal experiments.
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